The environment is primarily made up of dry, arid scrub. The palo santo woodland and the largest prickly pear cactus (Opuntia Echios) in the archipelago are both popular attractions for tourists. Iguanas eating the lower limbs of the plant resulted in an evolutionary reaction that gave rise to the immense height and girth of the cactus on the island. The landscape is usually a combination of turquoise blue waters and green/red vegetation.

Moreover, the wildlife in this Island consists of two different species of Galapagos Land Iguana, including the endemic Barrington Land Iguana, Galápagos Hawks, mockingbirds and Darwin Finches. Nevertheless, visitors could also encounter Sea Lions that lay all day on the beaches of this Island. Santa Fe has room for many activities but only one visitor site and two hiking paths are present. Barrington Bay’s calm waters are also suitable for kayaking and snorkeling, and there are three diving sites there as well.